Related MeSH Hierarchy (6)
Diseases [C] » Nervous System Diseases [C10] » Autoimmune Diseases of the Nervous System » Myasthenia Gravis » Myasthenia Gravis, Autoimmune, Experimental
Diseases [C] » Nervous System Diseases [C10] » Autoimmune Diseases of the Nervous System » Nervous System Autoimmune Disease, Experimental » Myasthenia Gravis, Autoimmune, Experimental
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Neuromuscular Junction Diseases » Myasthenia Gravis » Myasthenia Gravis, Autoimmune, Experimental
Diseases [C] » Immune System Diseases [C20] » Autoimmune Diseases » Autoimmune Diseases of the Nervous System » Myasthenia Gravis » Myasthenia Gravis, Autoimmune, Experimental
Diseases [C] » Immune System Diseases [C20] » Autoimmune Diseases » Autoimmune Diseases of the Nervous System » Nervous System Autoimmune Disease, Experimental » Myasthenia Gravis, Autoimmune, Experimental
Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E] » Investigative Techniques [E05] » Models, Animal » Disease Models, Animal » Nervous System Autoimmune Disease, Experimental » Myasthenia Gravis, Autoimmune, Experimental
Description
Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3) MeSH
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