Hypokalemic Periodic Paralysis D020514

Related MeSH Hierarchy (4)

Diseases [C] » Musculoskeletal Diseases [C05] » Muscular Diseases » Paralyses, Familial Periodic » Hypokalemic Periodic Paralysis

Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Muscular Diseases » Paralyses, Familial Periodic » Hypokalemic Periodic Paralysis

Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Metabolism, Inborn Errors » Metal Metabolism, Inborn Errors » Paralyses, Familial Periodic » Hypokalemic Periodic Paralysis

Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Metabolism, Inborn Errors » Metal Metabolism, Inborn Errors » Paralyses, Familial Periodic » Hypokalemic Periodic Paralysis

Description

An autosomal dominant familial disorder characterized by recurrent episodes of skeletal muscle weakness associated with falls in serum potassium levels. The condition usually presents in the first or second decade of life with attacks of trunk and leg paresis during sleep or shortly after awakening. Symptoms may persist for hours to days and generally are precipitated by exercise or a meal high in carbohydrates. (Adams et al., Principles of Neurology, 6th ed, p1483)   MeSH

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Approved Indicated Drugs (1)

diclofenamide

Phase 2 Indicated Drugs (1)

bumetanide (bumex)


Organization Involved with Phase 3 Indications (4)

National Center for Research Resources (NCRR)

National Institute of Neurological Disorders and Stroke (NINDS)

Ohio State University

University of Rochester

Organization Involved with Phase 2 Indications (1)

University of London

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