Related MeSH Hierarchy (4)
Diseases [C] » Musculoskeletal Diseases [C05] » Muscular Diseases » Muscular Disorders, Atrophic » Muscular Dystrophies » Muscular Dystrophy, Duchenne
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Muscular Diseases » Muscular Disorders, Atrophic » Muscular Dystrophies » Muscular Dystrophy, Duchenne
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Genetic Diseases, X-Linked » Muscular Dystrophy, Duchenne
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Muscular Dystrophies » Muscular Dystrophy, Duchenne
Description
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415) MeSH
Hierarchy View
Phase 4 Indicated Drugs (4)
Phase 3 Indicated Drugs (20)
Phase 2 Indicated Drugs (20)
Other Experimental Indicated Drugs (5)
Organization Involved with Phase 4 Indications (7)
Organization Involved with Phase 3 Indications (52)
Children's National Medical Center
Chinese Academy of Medical Sciences
Cooperative International Neuromuscular Research Group
Federal University of Minas Gerais
Katholieke Universiteit Leuven
Methodist Cancer Center, Houston, Texas
National Center for Research Resources (NCRR)
National Institute of Neurological Disorders and Stroke (NINDS)
Organization Involved with Phase 2 Indications (55)
Foundation to Eradicate Duchenne
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Instituto Mexicano del Seguro Social
Instituto Nacional de Rehabilitacion
National Center of Neurology and Psychiatry, Japan
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Organization Involved with Phase 1 Indications (26)
Organization Involved with Other Experimental Indications (4)
Hierarchy Tree View
UMLS Data
YOU AGREE THAT THE INFORMATION PROVIDED ON THIS WEBSITE IS PROVIDED “AS IS”, WITHOUT ANY WARRANTY OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION WARRANTIES OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE, OR NON-INFRINGEMENT OF ANY THIRD-PARTY PATENT, COPYRIGHT, OR ANY OTHER THIRD-PARTY RIGHT. IN NO EVENT SHALL THE CREATORS OF THE WEBSITE OR WASHINGTON UNIVERSITY BE LIABLE FOR ANY DIRECT, INDIRECT, SPECIAL, OR CONSEQUENTIAL DAMAGES ARISING OUT OF OR IN ANY WAY CONNECTED WITH THE WEBSITE, THE USE OF THE WEBSITE, OR THIS AGREEMENT, WHETHER IN BREACH OF CONTRACT, TORT OR OTHERWISE, EVEN IF SUCH PARTY IS ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.
