Related MeSH Hierarchy (4)
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Basal Ganglia Diseases » Parkinsonian Disorders » Parkinson Disease, Secondary » MPTP Poisoning
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Movement Disorders » Parkinsonian Disorders » Parkinson Disease, Secondary » MPTP Poisoning
Diseases [C] » Nervous System Diseases [C10] » Neurotoxicity Syndromes » MPTP Poisoning
Diseases [C] » Chemically-Induced Disorders [C25] » Poisoning » Neurotoxicity Syndromes » MPTP Poisoning
Description
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8) MeSH
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