Related MeSH Hierarchy (4)
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Metabolism, Inborn Errors » Amino Acid Metabolism, Inborn Errors » Hyperhomocysteinemia
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Malabsorption Syndromes » Hyperhomocysteinemia
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Metabolism, Inborn Errors » Amino Acid Metabolism, Inborn Errors » Hyperhomocysteinemia
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Nutrition Disorders » Malnutrition » Deficiency Diseases » Avitaminosis » Vitamin B Deficiency » Hyperhomocysteinemia
Description
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy. MeSH
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Subtype Terms (1)
Homocystinuria
6 drugs (3 approved, 3 experimental)
Phase 4 Indicated Drugs (5)
Phase 3 Indicated Drugs (5)
Phase 2 Indicated Drugs (1)
Phase 1 Indicated Drugs (1)
Other Experimental Indicated Drugs (4)
Organization Involved with Phase 4 Indications (9)
Organization Involved with Phase 3 Indications (15)
Organization Involved with Phase 1 Indications (5)
Organization Involved with Other Experimental Indications (8)
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