Aphasia, Primary Progressive D018888

Related MeSH Hierarchy (4)

Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Dementia » Aphasia, Primary Progressive

Psychiatry and Psychology [F] » Mental Disorders [F03] » Neurocognitive Disorders » Dementia » Aphasia, Primary Progressive

Description

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)   MeSH

Subtype Terms (1)

Primary Progressive Nonfluent Aphasia
5 drugs (1 approved, 4 experimental)


Phase 2 Indicated Drugs (1)

Phase 1 Indicated Drugs (2)

Other Experimental Indicated Drugs (1)


Organization Involved with Phase 3 Indications (4)

Organization Involved with Other Experimental Indications (3)

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UMLS Data


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