Related MeSH Hierarchy (4)
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Dementia » Aphasia, Primary Progressive
Diseases [C] » Nervous System Diseases [C10] » Neurologic Manifestations » Neurobehavioral Manifestations » Communication Disorders » Language Disorders » Speech Disorders » Aphasia » Aphasia, Primary Progressive
Diseases [C] » Pathological Conditions, Signs and Symptoms [C23] » Signs and Symptoms » Neurologic Manifestations » Neurobehavioral Manifestations » Communication Disorders » Language Disorders » Speech Disorders » Aphasia » Aphasia, Primary Progressive
Psychiatry and Psychology [F] » Mental Disorders [F03] » Neurocognitive Disorders » Dementia » Aphasia, Primary Progressive
Description
A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26) MeSH
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Subtype Terms (1)
Primary Progressive Nonfluent Aphasia
5 drugs (1 approved, 4 experimental)
Phase 2 Indicated Drugs (2)
Phase 1 Indicated Drugs (2)
Other Experimental Indicated Drugs (1)
Organization Involved with Phase 4 Indications (7)
Organization Involved with Phase 3 Indications (4)
Organization Involved with Phase 2 Indications (26)
Organization Involved with Phase 1 Indications (12)
Organization Involved with Other Experimental Indications (3)
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UMLS Data
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