Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » Ion Channels » Ligand-Gated Ion Channels » Receptors, Ionotropic Glutamate » Receptors, N-Methyl-D-Aspartate
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Glycoproteins » Ion Channels » Ligand-Gated Ion Channels » Receptors, Ionotropic Glutamate » Receptors, N-Methyl-D-Aspartate
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Ion Channels » Ligand-Gated Ion Channels » Receptors, Ionotropic Glutamate » Receptors, N-Methyl-D-Aspartate
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Neurotransmitter » Receptors, Amino Acid » Receptors, Glutamate » Receptors, Ionotropic Glutamate » Receptors, N-Methyl-D-Aspartate
Description
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. MeSH
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Other Experimental Indicated Drugs (1)
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