Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intercellular Signaling Peptides and Proteins » Cytokines » Hematopoietic Cell Growth Factors » Colony-Stimulating Factors » Granulocyte-Macrophage Colony-Stimulating Factor
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Glycoproteins » Colony-Stimulating Factors » Granulocyte-Macrophage Colony-Stimulating Factor
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intercellular Signaling Peptides and Proteins » Cytokines » Hematopoietic Cell Growth Factors » Colony-Stimulating Factors » Granulocyte-Macrophage Colony-Stimulating Factor
Chemicals and Drugs [D] » Biological Factors [D23] » Intercellular Signaling Peptides and Proteins » Cytokines » Hematopoietic Cell Growth Factors » Colony-Stimulating Factors » Granulocyte-Macrophage Colony-Stimulating Factor
Description
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages. MeSH
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