Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Phosphotransferases » Phosphotransferases (Alcohol Group Acceptor) » Protein Kinases » Protein-Tyrosine Kinases » Proto-Oncogene Proteins c-abl » Fusion Proteins, bcr-abl
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Mutant Proteins » Mutant Chimeric Proteins » Oncogene Proteins, Fusion » Fusion Proteins, bcr-abl
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Oncogene Proteins » Oncogene Proteins, Fusion » Fusion Proteins, bcr-abl
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Oncogene Proteins » Proto-Oncogene Proteins » Proto-Oncogene Proteins c-bcr » Fusion Proteins, bcr-abl
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Protein-Tyrosine Kinases » Proto-Oncogene Proteins c-abl » Fusion Proteins, bcr-abl
Description
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC. MeSH
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