Related MeSH Hierarchy (6)
Diseases [C] » Nervous System Diseases [C10] » Autoimmune Diseases of the Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome
Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Paraneoplastic Syndromes, Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Neuromuscular Junction Diseases » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome
Diseases [C] » Immune System Diseases [C20] » Autoimmune Diseases » Autoimmune Diseases of the Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome
Diseases [C] » Neoplasms [C04] » Neoplasms by Site » Nervous System Neoplasms » Paraneoplastic Syndromes, Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome
Diseases [C] » Neoplasms [C04] » Paraneoplastic Syndromes » Paraneoplastic Syndromes, Nervous System » Myasthenia Gravis » Lambert-Eaton Myasthenic Syndrome
Description
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471) MeSH
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Approved Indicated Drugs (2)
Organization Involved with Phase 3 Indications (3)
Organization Involved with Phase 2 Indications (4)
Organization Involved with Phase 1 Indications (1)
Organization Involved with Other Experimental Indications (9)
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UMLS Data
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