Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Lyases » Carbon-Carbon Lyases » Carboxy-Lyases » Uroporphyrinogen Decarboxylase
Description
An enzyme that catalyzes the decarboxylation of UROPORPHYRINOGEN III to coproporphyrinogen III by the conversion of four acetate groups to four methyl groups. It is the fifth enzyme in the 8-enzyme biosynthetic pathway of HEME. Several forms of cutaneous PORPHYRIAS are results of this enzyme deficiency as in PORPHYRIA CUTANEA TARDA; and HEPATOERYTHROPOIETIC PORPHYRIA. MeSH
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