Diseases [C] » Cardiovascular Diseases [C14] » Vascular Diseases » Hemostatic Disorders » Shwartzman Phenomenon
Diseases [C] » Cardiovascular Diseases [C14] » Vascular Diseases » Vasculitis » Shwartzman Phenomenon
Diseases [C] » Hemic and Lymphatic Diseases [C15] » Hematologic Diseases » Hemorrhagic Disorders » Hemostatic Disorders » Shwartzman Phenomenon
Description
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow. MeSH
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