Diseases [C] » Neoplasms [C04] » Neoplasms by Histologic Type » Neoplasms, Nerve Tissue » Nerve Sheath Neoplasms » Neurofibroma
Diseases [C] » Nervous System Diseases [C10] » Nervous System Neoplasms » Peripheral Nervous System Neoplasms » Nerve Sheath Neoplasms » Neurofibroma
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Peripheral Nervous System Diseases » Peripheral Nervous System Neoplasms » Nerve Sheath Neoplasms » Neurofibroma
Description
A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016) MeSH
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Subtype Terms (3)
Neurofibroma, Plexiform
17 drugs (11 approved, 6 experimental)
Neurofibromatoses
18 drugs (15 approved, 3 experimental)
Neurofibrosarcoma
35 drugs (25 approved, 10 experimental)
Phase 3 Indicated Drugs (1)
Organization Involved with Phase 4 Indications (1)
Organization Involved with Phase 3 Indications (5)
Organization Involved with Phase 2 Indications (62)
Betta Pharmaceuticals Co.,Ltd.
Children's National Medical Center
Memorial Sloan-Kettering Cancer Center
National Institutes of Health (NIH)
Sarcoma Alliance for Research through Collaboration
Simcere Pharmaceutical Co., Ltd
SpringWorks Therapeutics, Inc.
Texas Neurofibromatosis Foundation
The Children's Tumor Foundation
The Pacific Pediatric Neuro-Oncology Consortium
The University of Texas, Dallas
University of Alabama, Birmingham
University of British Columbia
Organization Involved with Phase 1 Indications (6)
Organization Involved with Other Experimental Indications (1)
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UMLS Data
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