Neurofibroma D009455

Description

A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016)   MeSH

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Subtype Terms (3)

Neurofibroma, Plexiform
15 drugs (11 approved, 4 experimental)

Neurofibromatoses
16 drugs (14 approved, 2 experimental)

Neurofibrosarcoma
33 drugs (25 approved, 8 experimental)


Phase 3 Indicated Drugs (1)


Organization Involved with Phase 4 Indications (1)

Organization Involved with Phase 2 Indications (62)

Organization Involved with Other Experimental Indications (1)

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UMLS Data


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