A moderately firm, benign, encapsulated tumor resulting from proliferation of SCHWANN CELLS and FIBROBLASTS that includes portions of nerve fibers. The tumors usually develop along peripheral or cranial nerves and are a central feature of NEUROFIBROMATOSIS 1, where they may occur intracranially or involve spinal roots. Pathologic features include fusiform enlargement of the involved nerve. Microscopic examination reveals a disorganized and loose cellular pattern with elongated nuclei intermixed with fibrous strands. (From Adams et al., Principles of Neurology, 6th ed, p1016) MeSH
Phase 3 Indicated Drugs (1)
Organization Involved with Phase 4 Indications (1)
Organization Involved with Phase 3 Indications (5)
Organization Involved with Phase 2 Indications (62)
Organization Involved with Other Experimental Indications (1)
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