Chemicals and Drugs [D] » Heterocyclic Compounds [D03] » Heterocyclic Compounds, Fused-Ring » Heterocyclic Compounds, 2-Ring » Pteridines » Pterins » Aminopterin » Methotrexate
Description
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. MeSH
Hierarchy View
Approved Indicated Drugs (1)
Phase 4 Indicated Drugs (13)
Phase 3 Indicated Drugs (1)
Hierarchy Tree View
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