Related MeSH Hierarchy (6)
Diseases [C] » Pathological Conditions, Signs and Symptoms [C23] » Pathologic Processes » Hyperbilirubinemia » Kernicterus
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Brain Diseases, Metabolic » Kernicterus
Diseases [C] » Hemic and Lymphatic Diseases [C15] » Hematologic Diseases » Erythroblastosis, Fetal » Kernicterus
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Infant, Newborn, Diseases » Erythroblastosis, Fetal » Kernicterus
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Brain Diseases, Metabolic » Kernicterus
Diseases [C] » Immune System Diseases [C20] » Erythroblastosis, Fetal » Kernicterus
Description
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) MeSH
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