Hemoglobinuria, Paroxysmal D006457

Diseases [C] » Hemic and Lymphatic Diseases [C15] » Hematologic Diseases » Anemia » Anemia, Hemolytic » Hemoglobinuria, Paroxysmal

Diseases [C] » Hemic and Lymphatic Diseases [C15] » Hematologic Diseases » Bone Marrow Diseases » Myelodysplastic Syndromes » Hemoglobinuria, Paroxysmal

Description

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.   MeSH

Approved Indicated Drugs (1)

Phase 1 Indicated Drugs (4)


Organization Involved with Phase 4 Indications (1)

Organization Involved with Other Experimental Indications (1)

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