Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Lyases » Ferrochelatase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Iron-Binding Proteins » Nonheme Iron Proteins » Iron-Sulfur Proteins » Ferrochelatase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Metalloproteins » Iron-Binding Proteins » Nonheme Iron Proteins » Iron-Sulfur Proteins » Ferrochelatase
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Mitochondrial Proteins » Ferrochelatase
Description
A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA. MeSH
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