Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Glycosyltransferases » Pentosyltransferases » ADP Ribose Transferases » Diphtheria Toxin
Chemicals and Drugs [D] » Biological Factors [D23] » Toxins, Biological » Bacterial Toxins » Diphtheria Toxin
Description
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells. MeSH
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