Related MeSH Hierarchy (4)
Phenomena and Processes [G] » Cell Physiological Phenomena [G04] » Cell Differentiation » Hematopoiesis » Clonal Hematopoiesis
Phenomena and Processes [G] » Cell Physiological Phenomena [G04] » Clonal Evolution » Clonal Hematopoiesis
Phenomena and Processes [G] » Genetic Phenomena [G05] » Clonal Evolution » Clonal Hematopoiesis
Phenomena and Processes [G] » Circulatory and Respiratory Physiological Phenomena [G09] » Blood Physiological Phenomena » Hematopoiesis » Clonal Hematopoiesis
Description
Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP). MeSH
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Phase 2 Indicated Drugs (16)
Phase 1 Indicated Drugs (1)
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