Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Protein Serine-Threonine Kinases » TOR Serine-Threonine Kinases » Mechanistic Target of Rapamycin Complex 1 » mTOR Associated Protein, LST8 Homolog
Chemicals and Drugs [D] » Macromolecular Substances [D05] » Multiprotein Complexes » Mechanistic Target of Rapamycin Complex 1 » mTOR Associated Protein, LST8 Homolog
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Phosphotransferases » Phosphotransferases (Alcohol Group Acceptor) » Protein Kinases » Protein Serine-Threonine Kinases » TOR Serine-Threonine Kinases » Mechanistic Target of Rapamycin Complex 1 » mTOR Associated Protein, LST8 Homolog
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Peptides » Intracellular Signaling Peptides and Proteins » Adaptor Proteins, Signal Transducing » mTOR Associated Protein, LST8 Homolog
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Adaptor Proteins, Signal Transducing » mTOR Associated Protein, LST8 Homolog
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Adaptor Proteins, Signal Transducing » mTOR Associated Protein, LST8 Homolog
Description
An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity. MeSH
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Phase 2 Indicated Drugs (1)
Other Experimental Indicated Drugs (1)
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