Active Ingredient History
Revefenacin (trade name Yupelri is a long-acting muscarinic antagonist developed by Mylan Ireland ltd for the treatment of chronic obstructive pulmonary disease (COPD). It has similar affinity to the subtypes of muscarinic receptors M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation. The competitive and reversible nature of antagonism was shown with human and animal origin receptors and isolated organ preparations. In preclinical in vitro as well as in vivo models, prevention of methacholine- and acetylcholine-induced bronchoconstrictive effects was dose-dependent and lasted longer than 24 hours. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Pulmonary Disease, Chronic Obstructive (approved 2018)
Healthy Volunteers (Phase 1)
Inspiratory Capacity (Phase 3)
Kidney Failure, Chronic (Phase 1/Phase 2)
Liver Diseases (Phase 1/Phase 2)
Lung Diseases (Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
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