pibrentasvir (Mavyret) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Priority Review FDA
AACT ChEMBL DrugBank PubChem

Active Ingredient History

NOW
  • Now
Pibrentasvir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS5A inhibitor that targets the the viral RNA replication and viron assembly. NS5A is a phosphoprotein that plays an essential role in replication, assembly and maturation of infectious viral proteins. The basal phosphorylated form of NS5A, which is maintained by C-terminal serine cluster, is key in ensuring its interaction with the viral capsid protein, or the core protein. By blocking this interaction, pibrentasvir inhibits the assembly of proteins and production of mature HCV particles. In the United States and Europe, Pibrentasvir is approved for use with glecaprevir as the combination drug glecaprevir/pibrentasvir (trade name Mavyret in the US and Maviret in the EU) for the treatment of hepatitis C. This fixed-dose combination therapy was FDA-approved in August 2017 to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis, including patients with moderate to severe kidney disease and those who are on dialysis.   NCATS

Chemistry

  • SMILES: CO[C@H](C)[C@H](NC(=O)OC)C(=O)N1CCC[C@H]1C2=NC3=C(N2)C=C(F)C(=C3)[C@H]4CC[C@@H](N4C5=CC(F)=C(N6CCC(CC6)C7=CC=C(F)C=C7)C(F)=C5)C8=CC9=C(NC(=N9)[C@@H]%10CCCN%10C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC)C=C8F
  • InChIKey: VJYSBPDEJWLKKJ-NLIMODCCSA-N
  • Mol. Mass: 1113.1802
  • ALogP: Missing data
  • ChEMBL Molecule:
    pibrentasvir  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( pibrentasvir (Mavyret), glecaprevir (Mavyret) - other name: glecaprevir and pibrentasvir )

Alternative names

a-1325912.0 | abt-530 | mavyret | pibrentasvir

Organizations (24)

Research & Development (23)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (21)

Approved Indications (1)


 

Hepatitis C, Chronic

Experimental Indications - Clinical Trial Phases 1-4 (21)


 

Analgesics, Opioid (Phase 4)

Heart Transplantation (Phase 4)

Hepacivirus (Phase 3)

Hepatitis C (Phase 4)

Hepatitis C, Chronic ()

Heroin Dependence (Phase 4)

HIV (Phase 4)

HIV Infections (Phase 2)

Infections (Phase 2)

Kidney Diseases (Phase 4)

Kidney Failure, Chronic (Phase 4)

Kidney Transplantation (Phase 4)

Liver Cirrhosis (Phase 3)

Liver Diseases (Phase 1)

Lung Transplantation (Phase 3)

Opioid-Related Disorders (Phase 4)

Renal Insufficiency (Phase 4)

Renal Insufficiency, Chronic (Phase 4)

Respiratory Insufficiency (Phase 4)

Risk Reduction Behavior (Phase 4)

Stress Disorders, Post-Traumatic (Phase 2/Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 54
  • # of Trial Organizations: 23

Trials by Phase

Trial Phase Start Date Organizations Indications

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