methacholine (provocholine) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Methacholine (trade name Provocholine) is a synthetic choline ester that acts as a muscarinic receptor agonist. Methacholine is primarily used to diagnose bronchial hyperreactivity, which is the hallmark of asthma and also occurs in chronic obstructive pulmonary disease. This is accomplished through the bronchial challenge test, or methacholine challenge, in which a subject inhales aerosolized methacholine, leading to bronchoconstriction.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$30.9000
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

acetyl-beta-methylcholine | acetylmethylcholine | beta-methylacetylcholine | mch | mecholin | mecholine | methachoine | methacholin | methacholine | methacholine chloride | provocholine

Organizations (32)

Research & Development (30)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (5)

Approved Indications (2)


 

Asthma (approved 1986)

Bronchial Hyperreactivity

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Asthma (Phase 4)

Cough (Phase 4)

Diabetes Mellitus (Phase 1)

Healthy Volunteers (Phase 1)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 28
  • # of Trial Organizations: 30

Trials by Phase

Trial Phase Start Date Organizations Indications

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