API | dosulepin

dosulepin (Prothiaden) Report issue

Small molecule Experimental

AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW

Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression. Dosulepin was once the most frequently prescribed antidepressant in the United Kingdom, but it is no longer widely used due to its relatively high toxicity in overdose without therapeutic advantages over other TCAs. It acts as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also has other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects. ^Wikipedia

Chemistry

SMILES: CN(C)CC\C=C\1/c2ccccc2CSc3ccccc13
InChIKey: PHTUQLWOUWZIMZ-GZTJUZNOSA-N
Mol. Mass: 295.45
ALogP: 4.68 Partition coefficient
ChEMBL Molecules:

dothiepin

dothiepin

dothiepin hydrochloride

More Chemistry

Pharmacology

Mechanisms of Action:
- 5-hydroxytryptamine receptor 1A (Homo sapiens) ^UniProt
- 5-hydroxytryptamine receptor 2A (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

Organizations (1)

Research & Development (1)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (1)

Approved Indications (1)

Depression

Experimental Indications - Clinical Trial Phases 1-4 (1)

Depression (Phase 4)

Overview

Highest Phase: Phase 4
# of Trials: 1
# of Trial Organizations: 1

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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