threonine Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central MeSH PubChem

Active Ingredient History

NOW
  • Now
L-threonine is an essential amino acid. Threonine is a precursor of glycine. The biochemical studies on rats proved that glycine is synthesized from threonine (through threonine dehydrogenase pathway). Threonine dehydrogenase is the key enzyme in mammals like pigs, cat, and rats for degradation of 80% threonine. In adult humans, degradation of 7–11% of threonine is done by threonine dehydrogenase. The human L-threonine 3-dehydrogenase gene (GeneID: 157739, UniProtKB: Q8IZJ6 (TDH_HUMAN)) is an expressed pseudogene having lost the splice acceptor site preceding exon 6 and codon arginine-214 (CGA) is mutated to a stop codon (TGA). A few trials demonstrated that oral L-threonine may alleviate clinical signs of amyotrophic lateral sclerosis and spasticity in humans. L-Threonine has recently been brought into agricultural industry for balancing the livestock feed.   NCATS

Chemistry

  • SMILES: C[C@@H](O)[C@H](N)C(O)=O
  • InChIKey: AYFVYJQAPQTCCC-GBXIJSLDSA-N
  • Mol. Mass: 119.1192
  • ALogP: -1.22
  • ChEMBL Molecule:
    threonine  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

2-amino-3-hydroxybutyric acid | (2s,3r)-(-)-threonine | (2s)-threonine | l-2-amino-3-hydroxybutyric acid | l-alpha-amino-beta-hydroxybutyric acid | l-threonin | l-threonine | l-(-)-threonine | l-α-amino-β-hydroxybutyric acid | thr | threonin | threonine

Organizations (1)

Research & Development (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (5)

Approved Indications (1)


 

Burns (approved 1971)

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Amyotrophic Lateral Sclerosis (Phase 2)

Healthy Volunteers (Phase 1)

Multiple Sclerosis (Phase 2)

Muscle Spasticity (Phase 2)

Overview

  • Highest Phase: Phase 1
  • # of Trials: 2
  • # of Trial Organizations: 1

Trials by Phase

Trial Phase Start Date Organizations Indications

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