Active Ingredient History

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Miconazole is a synthetic imidazole derivative, a topical antifungal agent for use in the local treatment of vaginal, and skin and nail infections due to yeasts and dermatophytes. It is particularly active against Candida spp., Trichophyton spp., Epidermophyton spp., Microsporum spp. and Pityrosporon orbiculare (Malassezia furfur), but also possesses some activity against Gram-positive bacteria. It binds to the heme moiety of the fungal cytochrome P-450 dependent enzyme lanosterol 14-alpha-demethlyase. Inhibits 14-alpha-demethlyase, blocks formation of ergosterol and leads to the buildup of toxic methylated 14-a-sterols. Miconazole also affects the synthesis of triglycerides and fatty acids and inhibits oxidative and peroxidative enzymes, increasing the amount of active oxygen species within the cell.   NCATS

  • SMILES: Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1
  • InChIKey: BYBLEWFAAKGYCD-UHFFFAOYSA-N
  • Mol. Mass: 416.14
  • ALogP: 6.45
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$0.0610 - $46.2700

Australia

$5.8148 - $8.8927
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1-[2-(2,4-dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1h-imidazole | 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole | acorvio | conofite | daktarin aktiv | daktarin iv | dermazole | dermonistat | dumicoat | femeron | gyno-daktarin | loramyc | micatin | miconazole | miconazole 3 | miconazole 3 combination pack | miconazole 7 | miconazole 7 combination pack | miconazole lauriad | miconazole nitrate | miconazole nitrate combination pack | miconazole oil | monistat | monistat 1 combination pack | monistat 3 | monistat-3 | monistat 3 combination pack | monistat-3 combination pack | monistat 3 combination pack (prefilled) | monistat 5 | monistat 7 | monistat 7 combination pack | monistat-derm | monistat iv (tn) | m-zole 3 combination pack | m-zole 7 dual pack | oravig | r-14889 | vusion

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