propoxyphene (Darvon) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Propoxyphene is a centrally acting opiate analgesic. Propoxyphene is an odorless, freely soluble in water, white crystalline powder with a bitter taste. In vitro studies demonstrated propoxyphene and the metabolite norpropoxyphene inhibit sodium channels (local anesthetic effect) with norpropoxyphene being approximately 2 fold more potent than propoxyphene and propoxyphene approximately 10 fold more potent than lidocaine. Propoxyphene and norpropoxyphene inhibit the voltage-gated potassium current carried by cardiac rapidly activating delayed rectifier (hERG) channels with approximately equal potency. It is unclear if the effects on ion channels occur within therapeutic dose range. Propoxyphene is indicated for the relief of mild to moderate pain.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( acetaminophen (tylenol), propoxyphene (Darvon) - other names: darvocet a, darvocet-n, wygesic )
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( caffeine, acetylsalicylic acid (aspirin), propoxyphene (Darvon) - other names: compoun, propoxyphene compoun )
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( acetylsalicylic acid (aspirin), propoxyphene (Darvon) - other name: darvon-n w/ asa )

Alternative names

2-naphthalenesulfonic acid, compd. with (s-(r*,s*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)p- ropyl propanoate (1:1) | darvon | darvon-n | dextropropoxyphene | dolene | doloxene | kesso-gesic | levopropoxyphene napsylate | levopropoxyphene napsylate anhydrous | levopropoxyphene napsylate, anhydrous | prophene 65 | propoxyphene | propoxyphene hcl | propoxyphene hydrochloride | propoxyphene hydrochloride 65 | propoxyphene napsylate | xp20b

Organizations (35)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (32)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (4)

Approved Indications (1)


 

Pain

Experimental Indications - Clinical Trial Phases 1-4 (3)


 

Acute Pain (Phase 3)

Healthy Volunteers (Phase 4)

Spinal Stenosis (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 3
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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