vorinostat (zolinza) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Priority Review FDA

Active Ingredient History

NOW
  • Now
Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL). Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized. Vorinostat is used for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies. Vorinostat is marketed under the name Zolinza by Merck for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after two systemic therapies.   NCATS

  • SMILES: ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1
  • InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N
  • Mol. Mass: 264.3202
  • ALogP: 2.47
  • ChEMBL Molecule:
More Chemistry
  • Mechanisms of Action: Missing data
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

Australia

$28.1451

United States

$93.2596 - $122.9681
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

18f-saha | 18f-suberoylanilide hydroxamic acid | m344 | merck brand of vorinostat | mk0683 | mk-0683 | n1-hydroxy-n8-phenyloctanediamide | nhnpoda | n-hydroxy-n'-phenyloctanediamide | n-hydroxy-n'-phenyl octanediamide | octanedioic acid hydroxyamide phenylamide | saha | shh | suberanilohydroxamic acid | suberoylanilide hydroxamic acid | vorinostat | vorinostatum | zolinza

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