Active Ingredient History
Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL). Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized. Vorinostat is used for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies. Vorinostat is marketed under the name Zolinza by Merck for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after two systemic therapies. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Lymphoma, T-Cell, Cutaneous (approved 2006)
Adenocarcinoma (Phase 2)
Alzheimer Disease (Phase 1)
Anemia (Phase 1)
Anemia, Refractory (Phase 2)
Anemia, Sickle Cell (Phase 2)
Anus Neoplasms (Phase 2)
Art (Phase 1)
Astrocytoma (Phase 2/Phase 3)
Bone Marrow Diseases (Phase 2)
Brain Neoplasms (Phase 2)
Breast Neoplasms (Phase 2)
Breast Neoplasms, Male (Phase 2)
Burkitt Lymphoma (Phase 2)
Carcinoma, Adenoid Cystic (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2/Phase 3)
Carcinoma, Renal Cell (Phase 2)
Carcinoma, Squamous Cell (Phase 2)
Carcinoma, Transitional Cell (Phase 1)
Carcinoma, Verrucous (Phase 1)
Central Nervous System Neoplasms (Phase 1)
Choriocarcinoma (Phase 1)
Choroid Plexus Neoplasms (Phase 1)
Colonic Neoplasms (Phase 2)
Colorectal Neoplasms (Phase 2)
Craniopharyngioma (Phase 1)
Crohn Disease (Phase 1/Phase 2)
Diffuse Intrinsic Pontine Glioma (Phase 1/Phase 2)
DNA Mismatch Repair (Phase 1)
Drug Resistant Epilepsy (Phase 2)
Endometrial Stromal Tumors (Phase 2)
Ependymoma (Phase 1)
Esophageal Neoplasms (Phase 1)
Fallopian Tube Neoplasms (Phase 1/Phase 2)
GATA2 Deficiency (Phase 1)
Genetic Diseases, Inborn (Phase 1/Phase 2)
Germinoma (Phase 1)
Glioblastoma (Phase 2)
Glioma (Phase 2/Phase 3)
Gliosarcoma (Phase 2)
Graft vs Host Disease (Phase 2)
Hamartoma (Phase 2)
Hematologic Diseases (Phase 2)
Hematologic Neoplasms (Phase 2)
Hematopoietic Stem Cell Transplantation (Phase 1)
Hepatoblastoma (Phase 1)
Histone Deacetylase Inhibitors (Phase 1/Phase 2)
HIV (Phase 2)
HIV Infections (Phase 2)
Hodgkin Disease (Phase 2)
Interleukins (Phase 1)
Intestinal Neoplasms (Phase 1)
Intraocular Lymphoma (Phase 2)
Leiomyosarcoma (Phase 2)
Leukemia (Phase 2)
Leukemia, Biphenotypic, Acute (Phase 2)
Leukemia, Eosinophilic, Acute (Phase 1)
Leukemia, Hairy Cell (Phase 2)
Leukemia, Large Granular Lymphocytic (Phase 1)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia-Lymphoma, Adult T-Cell (Phase 2)
Leukemia, Megakaryoblastic, Acute (Phase 1/Phase 2)
Leukemia, Monocytic, Acute (Phase 2)
Leukemia, Myeloid, Acute (Phase 3)
Leukemia, Myeloid, Chronic-Phase (Phase 2)
Leukemia, Myelomonocytic, Acute (Phase 2)
Leukemia, Myelomonocytic, Chronic (Phase 2)
Leukemia, Myelomonocytic, Juvenile (Phase 1)
Leukemia, Neutrophilic, Chronic (Phase 1)
Leukemia, Promyelocytic, Acute (Phase 1)
Liver Neoplasms (Phase 1)
Lung Neoplasms (Phase 3)
Lymphoma (Phase 3)
Lymphoma, AIDS-Related (Phase 1/Phase 2)
Lymphoma, B-Cell (Phase 2)
Lymphoma, B-Cell, Marginal Zone (Phase 2)
Lymphoma, Follicular (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 2)
Lymphoma, Large-Cell, Anaplastic (Phase 1/Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 2)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 2)
Lymphoma, Primary Effusion (Phase 1/Phase 2)
Lymphoma, T-Cell (Phase 2)
Lymphoma, T-Cell, Cutaneous (Phase 3)
Lymphoma, T-Cell, Peripheral (Phase 1)
Lymphomatoid Granulomatosis (Phase 2)
Medulloblastoma (Phase 1)
Melanoma (Phase 2)
Meningioma (Phase 1)
Mesothelioma (Phase 3)
Mesothelioma, Malignant (Phase 1/Phase 2)
Multiple Myeloma (Phase 3)
Mycosis Fungoides (Phase 2)
Myelodysplastic Syndromes (Phase 2)
Myeloproliferative Disorders (Phase 2)
Nasopharyngeal Carcinoma (Phase 1/Phase 2)
Nasopharyngeal Neoplasms (Phase 1/Phase 2)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 2)
Neoplasms, Germ Cell and Embryonal (Phase 1)
Neoplasms, Plasma Cell (Phase 1)
Neuroblastoma (Phase 2)
Neuroectodermal Tumors (Phase 1)
Oligodendroglioma (Phase 1)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 1/Phase 2)
Paraganglioma, Extra-Adrenal (Phase 1)
Pelvic Neoplasms (Phase 1)
Penile Neoplasms (Phase 2)
Pituitary ACTH Hypersecretion (Phase 2)
Plasmablastic Lymphoma (Phase 1/Phase 2)
Polycythemia Vera (Phase 2)
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Phase 1/Phase 2)
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (Phase 1/Phase 2)
Primary Myelofibrosis (Phase 1)
Prostatic Neoplasms (Phase 2)
Radiotherapy (Phase 1)
Rectal Neoplasms (Phase 1)
Rhabdoid Tumor (Phase 1)
Rhabdomyosarcoma (Phase 1)
Salivary Gland Neoplasms (Phase 2)
Sarcoma (Phase 2)
Sarcoma, Ewing (Phase 1)
Schizophrenia (Early Phase 1)
Sezary Syndrome (Phase 2)
Skin Neoplasms (Phase 1/Phase 2)
Small Cell Lung Carcinoma (Phase 1/Phase 2)
Spinal Cord Neoplasms (Phase 2/Phase 3)
Squamous Cell Carcinoma of Head and Neck (Phase 2)
Stomach Neoplasms (Phase 1/Phase 2)
Testicular Neoplasms (Phase 2)
Thrombocythemia, Essential (Phase 2)
Thrombocytopenia (Phase 2)
Thyroid Neoplasms (Phase 2)
Tongue Neoplasms (Phase 2)
Transplantation (Phase 2)
Urinary Bladder Neoplasms (Phase 2)
Uterine Cervical Neoplasms (Phase 2)
Uterine Neoplasms (Phase 2)
von Hippel-Lindau Disease (Phase 1)
Vulvar Neoplasms (Phase 2)
Waldenstrom Macroglobulinemia (Phase 2)
Wilms Tumor (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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