Active Ingredient History

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Verubecestat (MK-8931) was an experimental drug for the treatment of Alzheimer's disease. It is an inhibitor of beta-secretase 1 (BACE1), which, after initial promise proved disappointing.   Wikipedia

  • SMILES: CN1C(=N)N[C@@](C)(CS1(=O)=O)c2cc(NC(=O)c3ccc(F)cn3)ccc2F
  • InChIKey: YHYKUSGACIYRML-KRWDZBQOSA-N
  • Mol. Mass: 409.42
  • ALogP: 1.63
  • ChEMBL Molecule:
More Chemistry
mk-8931 | n-(3-(3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2h-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide | sch-900931 | verubecestat

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