verubecestat Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

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  • Now
Verubecestat (MK-8931) was an experimental drug for the treatment of Alzheimer's disease. It is an inhibitor of beta-secretase 1 (BACE1), which, after initial promise proved disappointing.   Wikipedia

Chemistry

  • SMILES: CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS1(=O)=O
  • InChIKey: YHYKUSGACIYRML-KRWDZBQOSA-N
  • Mol. Mass: 409.42
  • ALogP: 1.42
  • ChEMBL Molecule:
    verubecestat  
More Chemistry

Pharmacology

Alternative names

mk-8931 | n-(3-(3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2h-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoro-2-pyridinecarboxamide | sch-900931 | verubecestat

Organizations (1)

Research & Development (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Alzheimer Disease (Phase 3)

Cognition Disorders (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 5
  • # of Trial Organizations: 1

Trials by Phase

Trial Phase Start Date Organizations Indications

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