Active Ingredient History
Verapamil is a FDA approved drug used to treat high blood pressure and to control chest pain. Verapamil is an L-type calcium channel blocker that also has antiarrythmic activity. The R-enantiomer is more effective at reducing blood pressure compared to the S-enantiomer. However, the S-enantiomer is 20 times more potent than the R-enantiomer at prolonging the PR interval in treating arrhythmias. Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Arrhythmias, Cardiac (Phase 3)
Atrial Fibrillation (Phase 3)
Bipolar Disorder (Phase 3)
Blood Loss, Surgical (Early Phase 1)
Brain Neoplasms (Phase 2)
Cardiomyopathies (Phase 4)
Cardiomyopathy, Dilated (Phase 4)
Cardiovascular Diseases (Phase 3)
Catheterization (Phase 4)
Cluster Headache (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Vasospasm (Early Phase 1)
COVID-19 (Phase 2/Phase 3)
Crohn Disease (Phase 1)
Dermatology (Phase 4)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 3)
Diabetes Mellitus, Type 2 (Phase 1)
Dizziness (Phase 1)
Drug Interactions (Phase 1)
Drugs, Investigational (Early Phase 1)
Endoscopy (Early Phase 1)
Epilepsies, Myoclonic (Phase 2)
Epilepsy (Phase 2)
General Surgery (Phase 4)
Healthy Volunteers (Phase 1/Phase 2)
Heart Diseases (Phase 3)
Heart Failure, Systolic (Phase 4)
Heart Rate (Early Phase 1)
Hodgkin Disease (Phase 1)
Hypertension (Phase 4)
Hypertrophy, Left Ventricular (Phase 4)
Hypoglycemia (Phase 4)
Irritable Bowel Syndrome (Phase 3)
Ischemic Stroke (Phase 1)
Kidney Calculi (Phase 4)
Mania (Phase 3)
Marfan Syndrome (Phase 4)
Meningioma (Phase 2)
Metabolic Syndrome (Phase 4)
Migraine Disorders (Phase 1)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 4)
Nasal Polyps (Phase 1/Phase 2)
Neoplasms (Phase 2)
Obesity (Phase 4)
Opioid-Related Disorders (Phase 1)
Osteoarthritis, Knee (Phase 1/Phase 2)
Pain (Early Phase 1)
Percutaneous Coronary Intervention (Phase 4)
Pharmacokinetics (Phase 1)
Pharmacology (Phase 1)
Proteinuria (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 1)
Respiratory Syncytial Virus Infections (Phase 1)
Sinusitis (Phase 1/Phase 2)
Sleep Apnea, Obstructive (Phase 3)
Substance-Related Disorders (Phase 1)
Tachycardia, Ventricular (Phase 4)
Tinnitus (Phase 4)
Vasospasm, Intracranial (Phase 4)
Ventricular Fibrillation (Phase 2)
Verapamil (Early Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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