API | funapide

funapide Report issue

Small molecule Experimental

AACT ChEMBL DrugBank PubChem

Active Ingredient History

NOW

Funapide (INN) is a novel analgesic under development by Xenon Pharmaceuticals for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain. It acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker. Funapide is being evaluated in humans in both oral and topical formulations, and as of July 2014, has reached phase IIb clinical trials. ^Wikipedia

Chemistry

SMILES: FC(F)(F)c1oc(CN2C(=O)[C@@]3(COc4cc5OCOc5cc34)c6ccccc26)cc1
InChIKey: NEBUOXBYNAHKFV-NRFANRHFSA-N
Mol. Mass: 429.35
ALogP: 4.25 Partition coefficient
ChEMBL Molecule:
funapide

More Chemistry

Pharmacology

Mechanisms of Action:
- Sodium channel protein type 9 subunit alpha (Homo sapiens) ^UniProt
- Sodium channel protein type 10 subunit alpha (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

funapide | tv-45070 | xen-401-s | xen-402 | xpf-002

Organizations (5)

Research & Development (5)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (7)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (7)

Bunion (Phase 1)

Erythrocytes, Abnormal (Phase 1/Phase 2)

Erythromelalgia (Phase 1/Phase 2)

Neuralgia, Postherpetic (Phase 2)

Osteoarthritis, Knee (Phase 2)

Pain, Postoperative (Phase 1)

Pharmacokinetics (Phase 1)

Overview

Highest Phase: Phase 2
# of Trials: 6
# of Trial Organizations: 5

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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