Active Ingredient History
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Atherosclerosis (Phase 3)
Cardiovascular Diseases (Phase 3)
Coronary Disease (Phase 3)
Diabetes Mellitus (Phase 3)
Diabetes Mellitus, Type 2 (Phase 3)
Food-Drug Interactions (Phase 1)
Healthy Volunteers (Phase 1)
Hypercholesterolemia (Phase 3)
Hypertension (Phase 4)
Hypertrophy, Left Ventricular (Phase 4)
Lung Transplantation (Phase 4)
Obesity (Phase 3)
Sexual Dysfunction, Physiological (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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