Active Ingredient History
Misoprostol is a prostaglandin E1 (PGE1) analogue used for the treatment and prevention of stomach ulcers. When administered, misoprostol stimulates increased secretion of the protective mucus that lines the gastrointestinal tract and increases mucosal blood flow, thereby increasing mucosal integrity. It is sometimes co-prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) to prevent the occurrence of gastric ulceration, a common adverse effect of the NSAIDs. Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. The activity of this receptor is mediated by G proteins which normally activate adenylate cyclase. The indirect inhibition of adenylate cyclase by Misoprostol may be dependent on guanosine-5’-triphosphate (GTP). The significant cytoprotective actions of misoprostol are related to several mechanisms. These include: 1. Increased secretion of bicarbonate, 2. Considerable decrease in the volume and pepsin content of the gastric secretions, 3. It prevents harmful agents from disrupting the tight junctions between the epithelial cells which stops the subsequent back diffusion of H+ ions into the gastric mucosa, 4. Increased thickness of mucus layer, 5. Enhanced mucosal blood flow as a result of direct vasodilatation, 6. Stabilization of tissue lysozymes/vascular endothelium, 7. Improvement of mucosal regeneration capacity, and 8. Replacement of prostaglandins that have been depleted as a result of various insults to the area. Misoprostol has also been shown to increase the amplitude and frequency of uterine contractions during pregnancy via selective binding to the EP-2/EP-3 prostanoid receptors. Misoprostol is indicated for the treatment of ulceration (duodenal, gastric and NSAID induced) and prophylaxis for NSAID induced ulceration. Misoprostol is also indicated for other uses that are not approved in Canada, including the medical termination of an intrauterine pregnancy used alone or in combination with methotrexate, as well as the induction of labour in a selected population of pregnant women with unfavourable cervices. This indication is avoided in women with prior uterine surgery or cesarean surgery due to an increased risk of possible uterine rupture. Misoprostol is also used for the prevention or treatment of serious postpartum hemorrhage. Misoprostol is sold under the brandname Cytotec among others. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominal Injuries (Early Phase 1)
Abortifacient Agents, Nonsteroidal (Phase 3)
Abortion Applicants (Phase 4)
Abortion, Habitual (Phase 3)
Abortion, Incomplete (Phase 3)
Abortion, Induced (Phase 4)
Abortion, Legal (Phase 4)
Abortion, Missed (Phase 4)
Abortion, Spontaneous (Phase 4)
Abortion, Therapeutic (Phase 4)
Anemia (Phase 3)
Arthritis (Phase 3)
Arthritis, Rheumatoid (Phase 3)
Atrial Fibrillation (Phase 3)
Blood Loss, Surgical (Phase 4)
Bronchiectasis (Phase 4)
Catheters (Phase 4)
Cervical Ripening (Phase 4)
Cervix Uteri (Phase 4)
Cesarean Section (Phase 4)
Clostridioides difficile (Phase 2)
Constipation (Early Phase 1)
Contraception (Phase 4)
Contraceptive Devices (Phase 4)
Cytomegalovirus Infections (Phase 2)
Delivery, Obstetric (Phase 4)
Dermatology (Phase 4)
Endometrial Neoplasms (Phase 3)
Endometrium (Phase 3)
Family Planning Services (Phase 3)
Female Urogenital Diseases (Early Phase 1)
Fetal Death (Phase 4)
Fetal Development (Phase 4)
Fetal Membranes, Premature Rupture (Phase 4)
General Surgery (Phase 2/Phase 3)
Gestational Age (Phase 4)
Hemorrhage ()
Hysteroscopy (Phase 4)
Infant, Premature (Phase 4)
Infertility (Phase 3)
Intrauterine Devices (Phase 4)
Labor, Induced (Phase 4)
Labor, Obstetric (Phase 4)
Labor Pain (Phase 3)
Laparoscopy (Phase 4)
Leiomyoma (Phase 4)
Live Birth (Phase 4)
Liver (Phase 4)
Menorrhagia (Phase 4)
Menstruation Disturbances (Phase 4)
Misoprostol (Phase 4)
Myocardial Ischemia (Phase 3)
Myoma (Phase 4)
Nausea (Early Phase 1)
Neonatology (Phase 2/Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 2)
Obesity (Phase 4)
Obesity, Maternal (Phase 3)
Obstetric Labor, Premature (Phase 4)
Pain (Phase 2/Phase 3)
Peptic Ulcer ()
Placenta Previa (Phase 4)
Placenta, Retained (Phase 2)
Postpartum Hemorrhage (Phase 4)
Pre-Eclampsia (Phase 3)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 4)
Pregnancy Trimester, First (Phase 2)
Pregnancy Trimester, Second (Phase 4)
Pregnancy, Unwanted (Phase 4)
Premature Birth (Phase 2)
Respiratory Distress Syndrome (Phase 3)
Rupture, Spontaneous (Phase 4)
Spondylitis, Ankylosing (Phase 3)
Stomach Diseases (Phase 4)
Stomach Ulcer (Phase 3)
Tranexamic Acid (Phase 3)
Transient Tachypnea of the Newborn (Phase 3)
Uterine Cervical Diseases (Phase 4)
Uterine Diseases (Phase 4)
Uterine Hemorrhage (Phase 3)
Uterine Myomectomy (Phase 4)
Uterus (Phase 3)
Vaginal Diseases (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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