tivantinib Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Tivantinib is an experimental small molecule anti-cancer drug. It is a bisindolylmaleimide that binds to the dephosphorylated MET kinase in vitro. Tivantinib is being tested clinically as a highly selective MET inhibitor. However, the mechanism of action of tivantinib is still unclear.   Wikipedia

Chemistry

  • SMILES: O=C1NC(=O)[C@@H]([C@H]1C2=CNC3=C2C=CC=C3)C4=CN5CCCC6=CC=CC4=C56
  • InChIKey: UCEQXRCJXIVODC-WOJBJXKFSA-N
  • Mol. Mass: 369.4159
  • ALogP: 3.59
  • ChEMBL Molecule:
    tivantinib  
More Chemistry

Pharmacology

Alternative names

arq197 | arq 197 | arq-197 | tiv | tivantinib | tivantinib (arq 197) | (-)-trans-3-(5,6-dihydro-4h-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1h-indol-3-yl)pyrrolidin-2,5-dione

Organizations (75)

Research & Development (75)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (40)

Approved Indications (1)


 

Neoplasms

Experimental Indications - Clinical Trial Phases 1-4 (40)


 

Arthritis, Rheumatoid (Phase 4)

Asthma (Phase 3)

Breast Neoplasms (Phase 2)

Carcinoma, Hepatocellular (Phase 3)

Carcinoma, Non-Small-Cell Lung (Phase 3)

Carcinoma, Renal Cell (Phase 2)

Carcinoma, Small Cell (Phase 2)

Colorectal Neoplasms (Phase 2)

Dengue (Phase 2)

Dengue Virus (Phase 2)

Esophageal Neoplasms (Phase 1/Phase 2)

Fever (Phase 3)

Fibrosis (Phase 1)

Healthy Volunteers (Phase 4)

Influenza A Virus, H5N1 Subtype (Phase 3)

Influenza, Human (Phase 4)

Influenza in Birds (Phase 3)

Influenza Vaccines (Phase 3)

Liver Diseases (Phase 1)

Liver Neoplasms (Phase 3)

Mesothelioma (Phase 2)

Mesothelioma, Malignant (Phase 1/Phase 2)

Multiple Myeloma (Phase 2)

Neoplasms (Phase 1/Phase 2)

Neoplasms, Germ Cell and Embryonal (Phase 2)

Orthomyxoviridae (Phase 3)

Pancreatic Neoplasms (Phase 2)

Pandemics (Phase 2)

Pneumococcal Infections (Phase 4)

Prostatic Neoplasms (Phase 2)

Proto-Oncogene Proteins c-met (Phase 2)

Respiratory Syncytial Virus Infections (Phase 1)

Respiratory Tract Infections (Phase 3)

Sarcoma (Phase 2)

Sarcoma, Clear Cell (Phase 2)

Severe Dengue (Phase 2)

Small Cell Lung Carcinoma (Phase 1/Phase 2)

Squamous Cell Carcinoma of Head and Neck (Phase 2)

Stomach Neoplasms (Phase 2)

Vaccines (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 111
  • # of Trial Organizations: 75

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue