thiocolchicoside Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. Its mechanism of action is unknown, but it is believed to be act via antagonism of nicotinic acetylcholine receptors (nAchRs). However, it also appears to be a competitive antagonist of GABAA and glycine receptors. As such, it has powerful convulsant activity and should not be used in seizure-prone individuals.   Wikipedia

Chemistry

  • SMILES: COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2c(c1OC)-c1ccc(SC)c(=O)cc1C(NC(C)=O)CC2
  • InChIKey: LEQAKWQJCITZNK-MSQQGMGVSA-N
  • Mol. Mass: 563.63
  • ALogP: 0.75
  • ChEMBL Molecule:
    thiocolchicoside  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

2,14-di-(demethoxy)-2-glucosidoxy-14- methylthiocolchicine | coltramyl | miorel | muscoril | myoplège | thiocholshikoside | thiocolchicine 2-glucoside analog | thiocolchicine glycoside | thiocolchicoside

Organizations (4)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (5)

Approved Indications (1)


 

Spasm

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Low Back Pain (Phase 4)

Muscle Relaxation ()

Myofascial Pain Syndromes (Phase 4)

Temporomandibular Joint Disorders (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 6
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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