brinzolamide (azopt) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Brinzolamide reduces the amount of fluid in the eye, which decreases pressure inside the eye. Brinzolamide is a carbonic anhydrase inhibitor that is FDA approved for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Common adverse reactions include abnormal taste in mouth and blurred vision. The concomitant administration of brinzolamide and oral carbonic anhydrase inhibitors is not recommended. Plus, in patients treated with oral carbonic anhydrase inhibitors, rare instances of acid-base alterations have occurred with high-dose salicylate therapy.   NCATS

Chemistry

  • SMILES: CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O
  • InChIKey: HCRKCZRJWPKOAR-JTQLQIEISA-N
  • Mol. Mass: 383.507
  • ALogP: 0.09
  • ChEMBL Molecule:
    brinzolamide  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

Australia

$11.0248 - $14.7307

United States

$22.3810 - $32.9190
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( brimonidine (alphagan), brinzolamide (azopt) - other name: simbrinza 0.2%/1% ophthalmic suspension )

Alternative names

al-4862 | alcon brand of brinzolamide | allphar brand of brinzolamide | azopt | brinzolamide | brinzolamide / brimonidine tartrate | brinzolamide / timolol maleate | elazop

Organizations (37)

Research & Development (32)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (8)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (7)

Approved Indications (2)


 

Glaucoma, Open-Angle

Ocular Hypertension

Experimental Indications - Clinical Trial Phases 1-4 (7)


 

Central Serous Chorioretinopathy (Phase 2)

Glaucoma ()

Glaucoma, Open-Angle (Phase 4)

Infant (Phase 4)

Intraocular Pressure (Phase 4)

Ocular Hypertension ()

Posterior Capsule of the Lens (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 67
  • # of Trial Organizations: 32

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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