Active Ingredient History
Terazosin (marketed as Hytrin or Zayasel) is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. All three receptor subtypes appear to be involved in maintaining vascular tone. The α1A-receptor maintains basal vascular tone while the α1B-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of α1-receptors activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Hypertension (approved 2000)
Prostatic Hyperplasia (approved 2000)
Atherosclerosis (Phase 3)
Atrial Fibrillation (Phase 4)
Cardiovascular Diseases (Phase 3)
Carotid Stenosis (Phase 2)
Coronary Disease (Phase 3)
Diabetes Mellitus (Phase 3)
Diabetes Mellitus, Type 2 (Phase 4)
Directly Observed Therapy (Phase 4)
Ejaculation (Phase 1)
Gait Analysis (Phase 4)
Healthy Volunteers (Phase 1)
Hypercholesterolemia (Phase 3)
Hyperhidrosis (Phase 4)
Hypertension (Phase 4)
Lewy Body Disease (Phase 1/Phase 2)
Metabolic Diseases (Phase 4)
Parkinson Disease (Phase 4)
Parkinson Disease, Secondary (Phase 2)
Prostatic Hyperplasia (Phase 4)
REM Sleep Behavior Disorder (Phase 2)
Urination Disorders (Phase 2/Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
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