progenta Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Telapristone, as telapristone acetate, is a synthetic, steroidal selective progesterone receptor modulator (SPRM) related to mifepristone which is under development by Repros Therapeutics for the treatment of breast cancer, endometriosis, and uterine fibroids. It was originally developed by the National Institutes of Health (NIH), and, as of 2017, is in phase II clinical trials for the aforementioned indications. In addition to its activity as an SPRM, the drug also has some antiglucocorticoid activity.   Wikipedia

Chemistry

  • SMILES: COCC(=O)[C@@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C
  • InChIKey: JVBGZFRPTRKSBB-MJBQOYBXSA-N
  • Mol. Mass: 505.66
  • ALogP: 5.17
  • ChEMBL Molecule:
    telapristone acetate  
More Chemistry

Pharmacology

Alternative names

cdb4124 | cdb 4124 | cdb-4124 | proellex | progenta | ru-44675 | telapristone acetate

Organizations (5)

Research & Development (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (16)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (16)


 

Absorption (Phase 1)

Amenorrhea (Phase 1/Phase 2)

Anemia (Phase 3)

BRCA1 Protein (Phase 2)

Breast Neoplasms (Phase 2)

Drug Interactions (Phase 1)

Endometriosis (Phase 2)

Healthy Volunteers (Phase 1)

Intestinal Elimination (Phase 1)

Kidney Failure, Chronic (Phase 1/Phase 2)

Leiomyoma (Phase 3)

Liver Diseases (Phase 1)

Metabolism (Phase 1)

Mutation (Phase 2)

Pharmacokinetics (Phase 1)

Vagina (Phase 1)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 35
  • # of Trial Organizations: 5

Trials by Phase

Trial Phase Start Date Organizations Indications

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