Active Ingredient History
Terbinafine (brand name Lamisil, Terbisil, Terboderm and others) is an antifungal medication used to treat ringworm and fungal nail infections. Terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents the conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months). NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Onychomycosis (approved 1998)
Axial Spondyloarthritis (Early Phase 1)
Colitis, Ulcerative (Phase 2)
Crohn Disease (Phase 2)
Dermatomycoses (Phase 3)
Fasting (Phase 1)
Healthy Volunteers (Phase 1)
Inflammatory Bowel Diseases (Phase 2)
Intestinal Diseases (Early Phase 1)
Mycoses (Phase 2)
Neoplasms (Phase 2)
Onychomycosis (Phase 4)
Platelet-Rich Plasma (Phase 3)
Psoriasis (Early Phase 1)
Spondylarthropathies (Early Phase 1)
Spondylitis, Ankylosing (Early Phase 1)
Tinea (Phase 2/Phase 3)
Tinea Capitis (Phase 3)
Tinea cruris (Phase 2/Phase 3)
Tinea Pedis (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
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