Active Ingredient History
Levofloxacin is the L-isomer of the racemate, ofloxacin, a quinolone antimicrobial agent. Levofloxacin is used for oral and intravenous administration. Levofloxacin is sold under brand name levaquin and is used to treat infections in adults (≥18 years of age) caused by designated, susceptible bacteria such as, pneumonia: nosocomial and community acquired; skin and skin structure infections: complicated and uncomplicated; chronic bacterial prostatitis; inhalational anthrax. In addition this drug is used to treat plague; urinary tract infections: complicated and uncomplicated; acute pyelonephritis; acute bacterial exacerbation of chronic bronchitis and acute bacterial sinusitis. Levofloxacin, like other fluoroquinolones, inhibits the bacterial DNA gyrase, halting DNA replication. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing. In addition, levofloxacin inhibits a bacterial type II topoisomerase. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Bronchitis, Chronic (approved 1996)
Plague (approved 1996)
Prostatitis (approved 1996)
Staphylococcal Skin Infections (approved 1996)
Anesthesia and Analgesia (Phase 3)
Appendicitis (Phase 4)
Bacteremia (Phase 4)
Bacterial Infections (Phase 4)
Bacteriuria (Phase 3)
BCG Vaccine (Phase 4)
BK Virus (Phase 4)
Bone Diseases, Infectious (Phase 4)
Brain Neoplasms (Phase 3)
Breast Neoplasms (Phase 3)
Bronchiectasis (Phase 4)
Bronchitis (Phase 3)
Bronchitis, Chronic (Phase 3)
Cataract (Phase 4)
Cataract Extraction (Phase 4)
Cellulitis (Phase 2/Phase 3)
Cholangitis (Phase 4)
Community-Acquired Infections (Phase 4)
Conjunctivitis (Phase 1)
Conjunctivitis, Bacterial (Phase 2/Phase 3)
Corneal Diseases (Phase 1/Phase 2)
Corneal Transplantation (Phase 4)
COVID-19 (Phase 4)
Critical Illness (Phase 4)
Cross Infection (Phase 4)
Cystic Fibrosis (Phase 3)
Diabetic Foot (Phase 4)
Diarrhea (Phase 3)
Drug Delivery Systems (Phase 4)
Drug Misuse (Phase 4)
Dry Eye Syndromes (Phase 4)
Dyspepsia (Phase 4)
Endocarditis (Phase 4)
Endophthalmitis (Phase 4)
Escherichia coli Infections (Phase 1)
Extensively Drug-Resistant Tuberculosis (Phase 3)
Febrile Neutropenia (Phase 4)
Fever (Phase 4)
Gastritis (Phase 3)
General Surgery (Phase 3)
Healthcare-Associated Pneumonia (Phase 3)
Healthy Volunteers (Phase 4)
Heart Failure (Phase 3)
Helicobacter (Phase 3)
Helicobacter Infections (Phase 4)
Helicobacter pylori (Phase 4)
Hematopoietic Stem Cell Transplantation (Phase 2/Phase 3)
HIV (Phase 3)
HIV Infections (Phase 4)
Hyperopia (Phase 1/Phase 2)
Hypoglycemia (Phase 4)
Infections ()
Intensive Care Units (Phase 4)
Intestinal Neoplasms (Phase 4)
Keratitis (Phase 3)
Kidney Diseases (Phase 1)
Kidney Transplantation (Phase 4)
Latent Tuberculosis (Phase 3)
Leukemia (Phase 3)
Leukemia, Myeloid, Acute (Phase 3)
Lung Diseases (Phase 1)
Lung Neoplasms (Phase 3)
Lymphoma (Phase 3)
Lymphoma, Non-Hodgkin (Phase 2)
Maxillary Sinusitis (Phase 3)
Mucositis (Phase 4)
Multiple Myeloma (Phase 4)
Musculoskeletal Diseases (Phase 3)
Mycoses (Phase 3)
Myelodysplastic Syndromes (Phase 3)
Myopia (Phase 1/Phase 2)
Nasal Polyps (Phase 3)
Neoplasms (Phase 3)
Neutropenia (Phase 3)
Obesity (Phase 4)
Organ Transplantation (Phase 3)
Osteomyelitis (Phase 3)
Otitis Media (Phase 3)
Ovarian Neoplasms (Phase 3)
Pelvic Inflammatory Disease (Phase 3)
Peptic Ulcer (Phase 4)
Pharmacokinetics (Phase 1)
Pneumococcal Infections (Phase 4)
Pneumonia ()
Pneumonia, Aspiration (Phase 4)
Pneumonia, Bacterial (Phase 4)
Pneumonia, Pneumococcal (Phase 4)
Postoperative Complications (Phase 1/Phase 2)
Prostatic Hyperplasia (Phase 3)
Prostatic Neoplasms (Phase 4)
Prostatitis (Phase 3)
Prosthesis-Related Infections (Phase 2)
Pterygium (Phase 1/Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Pyelonephritis (Phase 4)
Respiratory Aspiration (Phase 4)
Sarcoidosis (Phase 2)
Sarcoidosis, Pulmonary (Phase 1)
Short Bowel Syndrome (Phase 1)
Sick Sinus Syndrome (Phase 3)
Sinusitis (Phase 4)
Skin Diseases, Bacterial (Phase 3)
Skin Diseases, Infectious (Phase 3)
Sprains and Strains (Phase 3)
Staphylococcus (Phase 3)
Staphylococcus aureus (Phase 4)
Syncope (Phase 3)
Testicular Neoplasms (Phase 3)
Tuberculosis (Phase 3)
Tuberculosis, Meningeal (Phase 1/Phase 2)
Tuberculosis, Multidrug-Resistant (Phase 4)
Tuberculosis, Pulmonary (Phase 4)
Urinary Bladder Neoplasms (Phase 4)
Urinary Bladder, Neurogenic (Phase 3)
Urinary Bladder, Overactive (Phase 1)
Urological Manifestations (Phase 1/Phase 2)
Urologic Diseases (Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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