tasquinimod Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Tasquinimod is an experimental drug currently being investigated for the treatment of solid tumors. Tasquinimod has been mostly studied in prostate cancer, but its mechanism of action suggests that it could be used to treat other cancers. Castration-resistant prostate cancer (CRPC), formerly called hormone-resistant or hormone-refractory prostate cancer, is prostate cancer that grows despite medical or surgical androgen deprivation therapy. Tasquinimod targets the tumor microenvironment and counteracts cancer development by inhibiting angiogenesis and metastasis and by modulating the immune system. It is now in phase III development, following successful phase II trial outcomes.   Wikipedia

Chemistry

  • SMILES: COc1cccc2N(C)C(=O)C(=C(O)c12)C(=O)N(C)c3ccc(cc3)C(F)(F)F
  • InChIKey: ONDYALNGTUAJDX-UHFFFAOYSA-N
  • Mol. Mass: 406.36
  • ALogP: 3.55
  • ChEMBL Molecule:
    tasquinimod  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-((4-trifluoromethyl)phenyl)-1,2-dihydroquinoline-3-carboxamide | abr-215050 | tasq | tasquinimod

Organizations (7)

Research & Development (7)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (8)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (8)


 

Carcinoma, Hepatocellular (Phase 2)

Carcinoma, Renal Cell (Phase 2)

Healthy Volunteers (Phase 1)

Multiple Myeloma (Phase 1)

Ovarian Neoplasms (Phase 2)

Prostatic Neoplasms (Phase 3)

Prostatic Neoplasms, Castration-Resistant (Phase 3)

Stomach Neoplasms (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 10
  • # of Trial Organizations: 7

Trials by Phase

Trial Phase Start Date Organizations Indications

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