Active Ingredient History

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Amorolfine, is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis. Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.   Wikipedia

  • SMILES: CCC(C)(C)c1ccc(CC(C)CN2C[C@@H](C)O[C@@H](C)C2)cc1
  • InChIKey: MQHLMHIZUIDKOO-AYHJJNSGSA-N
  • Mol. Mass: 317.52
  • ALogP: 4.66
  • ChEMBL Molecule:
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Drug Pricing (per unit)

Australia

$28.3450 - $63.2335
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

allphar brand of amorolfine hydrochloride | amorolfine | amorolfine hcl | amorolfine hydrochloride | amorolfin hydrochloride | galderma brand of amorolfine hydrochloride | isdin brand of amorolfine hydrochloride | loceryl | locéryl | loceryl curanail | locetar | odenil | omicur | ro-144767000 | ro 14-4767-002 | ro-14-4767-002 | roche brand of amorolfine hydrochloride

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