Active Ingredient History
Sorbitol is a polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. Used as a non-stimulant laxative via an oral suspension or enema. Sorbitol exerts its laxative effect by drawing water into the large intestine, thereby stimulating bowel movements. Sorbitol plays a vital step in the 'polyol pathway'. The sudden injection of extra sorbitol can ruin the equilibrium of enzymes that regulate the conversion of glucose to fructose in a process associated with the onset of diabetes and its complications. Further, the polyol pathway is involved with a complex network of metabolic activities; disruption leads to a cascade of problems (citations here, here and here) such as mitochondrial failure, cell apoptosis (cell death), and DNA fragmentation. In general, sorbitol induces cell hyperosmotic stress resulting in phosphorylation (uptake of phosphorus into cell) — an important on/off switch regulating enzymes and signaling networks. NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Acute Kidney Injury (approved 1964)
Asthma (approved 2010)
Brain Edema (approved 1964)
Cystic Fibrosis (approved 2012)
Intraocular Pressure (approved 1964)
Kidney Failure, Chronic (approved 1978)
Acute Pain (Phase 1/Phase 2)
Alcoholic Intoxication (Phase 4)
Alzheimer Disease (Phase 2)
Bacterial Infections (Phase 1/Phase 2)
Burns (Phase 4)
Cardiovascular Diseases (Phase 4)
Charcot-Marie-Tooth Disease (Phase 3)
Constipation (Phase 4)
Coronary Artery Disease (Phase 4)
COVID-19 (Phase 2/Phase 3)
Cumulative Trauma Disorders (Phase 2/Phase 3)
Dental Caries (Phase 2/Phase 3)
Gait (Phase 2/Phase 3)
General Surgery (Phase 4)
Glaucoma, Open-Angle (Phase 4)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 4)
HIV (Phase 4)
Ileus (Phase 4)
Injections (Phase 2/Phase 3)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Myocardial Ischemia (Phase 4)
Non-alcoholic Fatty Liver Disease (Phase 2)
Ocular Hypertension (Phase 4)
Osteoarthritis, Knee (Phase 2/Phase 3)
Parkinson Disease (Phase 2)
Peritonitis (Phase 4)
Pneumonia (Phase 4)
Sepsis (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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