sitaxentan Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Sitaxentan sodium (TBC-11251) is a medication for the treatment of pulmonary arterial hypertension (PAH). It was marketed as Thelin by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market due to concerns about liver toxicity.   Wikipedia

Chemistry

  • SMILES: Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2
  • InChIKey: PHWXUGHIIBDVKD-UHFFFAOYSA-N
  • Mol. Mass: 454.91
  • ALogP: 3.96
  • ChEMBL Molecules:
    sitaxentan  
    sitaxentan sodium  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Oral
  • Pro Drug: No

Alternative names

n-(4-chloro-3-methyl-5-isoxazolyl)-2-(3,4-(methylenedioxy)-6-methyl)phenylacetyl-3-thiophenesulfonamide | n-(4-chloro-3-methyl-5-isoxazolyl)-2-((4,5-(methylenedioxy)-o-toly)acetyl)-3-thiophenesulfonamide | sitaxentan | sitaxentan sodium | sitaxsentan | sitaxsentan sodium | tbc11251 | tbc 11251 | tbc-11251 | tbc-11251na | tbc-11251z

Organizations (5)

Research & Development (5)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (13)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (13)


 

Asthma (Phase 2)

Blood Pressure (Phase 2)

General Surgery (Phase 2)

Healthy Volunteers (Phase 1)

Heart Failure, Diastolic (Phase 2)

Heart Valve Diseases (Phase 2)

Hypertension, Pulmonary (Phase 3)

Lung Diseases (Phase 2)

Proteinuria (Phase 2)

Pulmonary Arterial Hypertension (Phase 3)

Renal Insufficiency, Chronic (Phase 2)

Vasoconstriction (Early Phase 1)

Vasodilation (Early Phase 1)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 18
  • # of Trial Organizations: 5

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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