Active Ingredient History

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Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, glyoxal, methylglyoxal, and related dicarbonyls. These reactive species are converted to less reactive heterocycles by this condensation reaction.   Wikipedia

aminoguanidine | aminoguanidine sulfate | hydrazinecarboximidamide | monoaminoguanidine | pimagedine | pimagedine hydrochloride

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