semustine Report issue

Small molecule Experimental
AACT ChEMBL Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Semustine is an alkylating nitrosourea compound used in chemotherapy treatment of various types of tumours. Due to its lipophilic property, semustine can cross the blood-brain barrier for the chemotherapy of brain tumours, where it interferes with DNA replication in the rapidly-dividing tumour cells. Semustine, just as lomustine, is administered orally. Evidence has been found that treatment with semustine can cause acute leukaemia as a delayed effect in very rare cases.   Wikipedia

Chemistry

  • SMILES: CC1CCC(CC1)NC(=O)N(CCCl)N=O
  • InChIKey: FVLVBPDQNARYJU-UHFFFAOYSA-N
  • Mol. Mass: 247.73
  • ALogP: 2.5
  • ChEMBL Molecule:
    semustine  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

methyl-ccnu | methyl lomustine | semustine

Organizations (16)

Research & Development (16)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (10)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (10)


 

Astrocytoma (Phase 3)

Colorectal Neoplasms (Phase 3)

Glioblastoma (Phase 3)

Graft vs Host Disease (Phase 3)

Hematopoietic Stem Cell Transplantation (Phase 2/Phase 3)

Leukemia (Phase 3)

Leukemia, Myeloid, Acute (Phase 2/Phase 3)

Lymphoma, T-Cell, Peripheral (Phase 3)

Recurrence (Phase 3)

Vascular Grafting (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 9
  • # of Trial Organizations: 16

Trials by Phase

Trial Phase Start Date Organizations Indications

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