Active Ingredient History
Vorapaxar is a tricyclic himbacine-derived oral thrombin receptor antagonist that acts by reversible inhibition of the protease-activated receptor-1 (PAR-1). PAR-1 is expressed on platelets and its inhibition prevents platelets from aggregation. Vorapaxar is approved by FDA and is indicated for the reduction of recurring thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease. Vorapaxar at the same time may cause bleeding complications including intracranial haemorrhage (ICH), when compared to standard therapy alone. That is why Vorapaxar is contraindicated in patients with prior stroke, transient ischemic attack and ICH. NCATS
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Acute Coronary Syndrome (Phase 1)
Arterial Occlusive Diseases (Phase 2)
Arteriovenous Fistula (Phase 2)
Atherosclerosis (Phase 3)
Cerebral Infarction (Phase 2)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 2)
Diabetes Mellitus (Phase 4)
Healthy Volunteers (Phase 4)
HIV (Phase 1/Phase 2)
Ischemia (Phase 3)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 3)
Peripheral Arterial Disease (Phase 4)
Peripheral Vascular Diseases (Phase 4)
Stroke (Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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