Active Ingredient History
Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin, to prevent thrombosis in patients with valvular or vascular disorders. Dipyridamole is also used in myocardial perfusion imaging, as an antiplatelet agent, and in combination with aspirin for stroke prophylaxis. Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation. Used for as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Anemia, Sickle Cell (Phase 2)
Angina Pectoris (Phase 3)
Angioplasty, Balloon, Coronary (Phase 4)
Arteriosclerosis (Phase 4)
Arthritis, Rheumatoid (Phase 2)
Atherosclerosis (Phase 4)
Atrial Fibrillation (Phase 2)
Bipolar Disorder (Phase 4)
Brain Ischemia (Phase 4)
Cardiovascular Diseases (Phase 4)
Carotid Artery Diseases (Phase 3)
Carotid Stenosis (Phase 2)
Cerebral Hemorrhage (Phase 3)
Cerebrovascular Disorders (Phase 2)
Cervix Uteri (Phase 3)
Coronary Angiography (Early Phase 1)
Coronary Disease (Phase 4)
Coronavirus Infections (Phase 2)
COVID-19 (Phase 3)
Cytokine Release Syndrome (Phase 2)
Diabetes Mellitus (Phase 4)
Dry Eye Syndromes (Phase 2)
Endotoxemia (Phase 4)
Fibrosis (Phase 4)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 3)
HIV Infections (Phase 1/Phase 2)
Hypertension (Phase 4)
Hypertension, Portal (Phase 4)
Ischemic Attack, Transient (Phase 4)
Mania (Phase 4)
Myocardial Ischemia (Phase 4)
Osteoarthritis, Knee (Phase 2)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 2)
Postoperative Nausea and Vomiting (Phase 2)
Pterygium (Phase 2)
Purpura (Phase 1/Phase 2)
Reperfusion Injury (Phase 4)
SARS-CoV-2 (Phase 2)
Splenectomy (Phase 4)
Stroke (Phase 3)
Takotsubo Cardiomyopathy (Phase 2)
Vascular Diseases (Phase 2)
Venous Thrombosis (Phase 4)
Vertebral Artery Dissection (Phase 3)
Xerostomia (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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