Active Ingredient History
Amitriptyline is a derivative of dibenzocycloheptadiene and a tricyclic antidepressant (TCA) and is mainly used to treat symptoms of depression. It works on the central nervous system (CNS) by inhibiting the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Amitriptyline has been frequently used as an active comparator in clinical trials on newer antidepressants. It is rarely used as a first-line antidepressant nowadays due to its high degree of toxicity in overdose and generally poorer tolerability than the newer antidepressants. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Amitriptyline (Phase 3)
Amputation, Traumatic (Phase 4)
Antioxidants (Phase 2)
Anxiety Disorders (Phase 4)
Autism Spectrum Disorder (Phase 3)
Behavior (Phase 3)
Biliary Dyskinesia (Phase 2)
Brain Injuries (Phase 2)
Bursitis (Phase 2)
Carpal Tunnel Syndrome (Phase 2)
Cerebral Palsy (Phase 4)
Chronic Pain (Phase 4)
Cough (Phase 2)
Crying (Phase 4)
Cumulative Trauma Disorders (Phase 2)
Cystic Fibrosis (Phase 2)
Cystitis, Interstitial (Phase 3)
Cytokines (Phase 2)
Dementia (Phase 3)
Depression (Phase 4)
Depressive Disorder, Major (Phase 3)
Diabetes Mellitus (Phase 2/Phase 3)
Diabetes Mellitus, Type 1 (Phase 2)
Enuresis (Phase 1)
Facial Pain (Phase 4)
Fibromyalgia (Phase 4)
Food (Phase 2)
Gastrointestinal Diseases (Phase 4)
Genital Diseases, Female (Phase 2/Phase 3)
Growth Hormone (Phase 2)
Headache (Phase 4)
Headache Disorders (Phase 4)
Head and Neck Neoplasms (Phase 2)
Healthy Volunteers (Phase 1)
HIV Infections (Phase 2)
Hypertension (Phase 1)
Hypoglycemia (Phase 2)
Infections (Phase 2)
Intervertebral Disc Displacement (Phase 2)
Irritable Bowel Syndrome (Phase 4)
Laryngeal Diseases (Phase 2/Phase 3)
Leprosy (Phase 3)
Leukemia (Phase 3)
Lung Diseases, Interstitial (Phase 2)
Lymphoma (Phase 3)
Lymphoproliferative Disorders (Phase 3)
Mandibular Diseases (Phase 2/Phase 3)
Metabolism (Phase 1)
Migraine Disorders (Phase 4)
Mood Disorders (Phase 4)
Multiple Myeloma (Phase 3)
Myelodysplastic Syndromes (Phase 3)
Myeloproliferative Disorders (Phase 3)
Myofascial Pain Syndromes (Phase 2/Phase 3)
Neck Pain (Phase 4)
Neoplasms (Phase 3)
Nerve Degeneration (Phase 3)
Neuralgia (Phase 3)
Neuralgia, Postherpetic (Phase 2)
Osteoarthritis, Knee (Phase 2/Phase 3)
Oxidative Stress (Phase 2)
Pain (Phase 4)
Pain, Postoperative (Phase 4)
Peripheral Nerve Injuries (Phase 2)
Peripheral Nervous System Diseases (Phase 3)
Pharmaceutical Preparations (Phase 2)
Pneumonia (Phase 2)
Post-Traumatic Headache (Phase 2)
Pruritus (Phase 2)
Pseudomonas aeruginosa (Phase 2)
Psychophysiologic Disorders (Phase 3)
Quality of Life (Phase 4)
Schizophrenia (Phase 4)
Selective Serotonin Reuptake Inhibitors (Phase 2)
Spinal Cord Injuries (Phase 4)
Sports Medicine (Phase 1)
Stomach Diseases (Phase 2/Phase 3)
Tinnitus (Phase 2)
Urinary Bladder Diseases (Phase 3)
Vulvodynia (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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