Active Ingredient History

NOW
  • Now
Dexamethasone acetate (NEOFORDEX®) is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regulation of nuclear factor-κB activity and an activation of caspase-9 through second mitochondria-derived activator of caspase (Smac; an apoptosis promoting factor) release. Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation. Dexamethasone also down-regulated anti apoptotic genes and increased IκB-alpha protein levels. Dexamethasone apoptotic activity is enhanced by the combination with thalidomide or its analogues and with proteasome inhibitor (e.g. bortezomib).   NCATS

More Chemistry
  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Parenteral
  • Pro Drug: Yes

Drug Pricing (per unit)

Australia

$0.0610 - $999.0128

United States

$0.1085 - $5307.0700
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

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( lidocaine (xylocaine), dexamethasone )
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( neomycin, polymyxin b sulfate (poly-rx), dexamethasone - other names: dexacidin, dexasporin, neomycin and polymyxin b sulfates and dexamethasone )
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( neomycin, dexamethasone )
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( tobramycin (nebcin), dexamethasone - other name: tobradex st )
21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione | aeroseb-dex | al-2512 | dalalone | decaderm | decadron | decadron-75 | decadronal | decadron-la | decadron phosphate | decaspray | dexacen-4 | dexacort | dexacortisyl | dexafree | dexair | dexamesathone | dexametasona | dexamethason | dexamethasone | dexamethasone 17-valerate | dexamethasone-21-acetate | dexamethasone 21-phosphate | dexamethasone 21-phosphate, (6alpha,11beta,16alpha)-isomer | dexamethasone 21-phosphate, copper (+2) salt (2:3), (11beta,16alpha)-isomer | dexamethasone 21-phosphate, disodium salt, (11beta,16alpha)-isomer | dexamethasone 21-phosphate, disodium salt, (6alpha,11beta,16alpha)-isomer | dexamethasone 21-phosphate, monosodium salt, (11beta,16alpha)-isomer | dexamethasone 21-phosphate, sodium salt, (11beta,16alpha)-isomer | dexamethasone acefurate | dexamethasone acetate | dexamethasone acetate, (6alpha,11beta)-isomer | dexamethasone cipecilate | dexamethasone dimenhidrinate | dexamethasone dipropionate | dexamethasonedisodium phosphate | dexamethasone intensol | dexamethasone loaded rbc | dexamethasone metasulfobenzoate sodium | dexamethasone mixture with tobramycin | dexamethasone palmitate | dexamethasone phosphate | dexamethasone phosphate disodium salt | dexamethasone phosphoric acid | dexamethasone propionate | dexamethasone sodium hemisulfate | dexamethasone sodium phosphate | dexamethasone sodium phosphate encapsulated erythrocytes | dexamethasone valerate | dexamethasonum | dexamethazone | dexamethazone beloxil | dexasone | dexmethsone | dexone | dexone 0.5 | dexone 0.75 | dexone 1.5 | dexone 4 | dexsol | dextralgen | dropodex | egp-437 | fluormethylprednisolone | gppe ear spy | hexadecadrol | hexadrol | ibi-10090 | kortico injection | martapan | maxidex | maxitrol | methaderm | mucolox | mymethasone | neodecadron | oradexon | otomize | ozurdex | rejuveinix | shp640 | sofradex | spersadex | spersadex comp | spersadox | tlc599

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